The Scientific World Journal

Research Article

Gene-Gene Interactions in Renin-Angiotensin-Aldosterone System Contributes to End-Stage Renal Disease Susceptibility in a Han Chinese Population

Table 3

AGT, AGTR1, ACE, and CYP11B2 gene polymorphisms with risk of different cause of ESRD.
 Diabetic nephropathy
( )
adjusted# OR (95% CI)		Hypertensive nephropathy
( )
adjusted# OR (95% CI)		Glomerulonephritis
( )
adjusted# OR (95% CI)		Systemic nephropathy
( )
adjusted# OR (95% CI)		Other&  
( )  
adjusted# OR (95% CI)
AGT     
 M235T     
  CT/CC0.75 (0.52–1.09)1.07 (0.58–1.98)0.51 (0.31–0.85)*0.97 (0.5–1.89)1.08 (0.59–1.99)
  TT/CC0.33 (0.09–1.14)—0.18 (0.02–1.41)—0.46 (0.06–3.55)
 T174M     
  CT/CC1.26 (0.84–1.88)1.10 (0.54–2.24)1.07 (0.66–1.75)0.79 (0.35–1.77)1.17 (0.58–2.36)
  TT/CC0.94 (0.17–5.07)—0.94 (0.10–8.55)2.58 (0.29–23.17)2.13 (0.23–19.54)
AGTR1     
 A1166C     
  AC/AA0.79 (0.42–1.47)0.96 (0.37–2.51)1.49 (0.81–2.74)0.72 (0.22–2.43)1.59 (0.68–3.74)
  CC/AA—————
 C573T     
  CT/CC1.30 (0.92–1.83)0.96 (0.54–1.70)1.32 (0.87–1.98)1.31 (0.69–2.49)1.00 (0.54–1.84)
  TT/CC0.68 (0.33–1.39)0.76 (0.26–2.25)0.59 (0.24–1.46)1.62 (0.61–4.35)1.4 (0.55–3.58)
ACE     
 ID     
  ID/II1.89 (1.31–2.71)*1.16 (0.64–2.11)1.35 (0.89–2.05)0.83 (0.42–1.61)1.22 (0.66–2.26)
  DD/II1.71 (0.97–3.00)2.21 (1.01–4.83)*1.03 (0.5–2.13)2.07 (0.93–4.64)1.99 (0.85–4.65)
 G2350A     
  GA/GG1.65 (1.14–2.40)*1.93 (1.02–3.63)*1.02 (0.66–1.56)1.92 (0.97–3.77)0.91 (0.49–1.68)
  AA/GG2.04 (1.28–3.28)*2.41 (1.11–5.22)*1.13 (0.63–2.04)2.17 (0.9–5.25)1.12 (0.5–2.53)
CYP11B2     
 C-344T     
  TC/TT0.75 (0.52–1.07)0.58 (0.32–1.04)0.73 (0.48–1.12)0.50 (0.25–0.99)*0.82 (0.44–1.55)
  CC/TT1.11 (0.61–2.00)0.53 (0.16–1.78)0.75 (0.34–1.68)1.55 (0.62–3.85)2.26 (0.99–5.15)
, adjusted for gender, age, BMI, and smoking status; Others: for example, kidney stone, polycystic kidney disease, and so forth.