Research Article

Gene-Gene Interactions in Renin-Angiotensin-Aldosterone System Contributes to End-Stage Renal Disease Susceptibility in a Han Chinese Population

Table 4

Best gene-gene interaction models identified by the MDR method.

Locus no.Best modelTesting Bal. Acc. (%) -value*

1ACE I/D0.5179 0.6520
2ACE I/D, ACE G2350A0.5537 0.0280
3ACE I/D, ACE G2350A, CYP11B2 C-344T0.5608 0.0060
4AGTR1 C573T, ACE I/D, ACE G2350A, CYP11B2 C-344T0.5499 0.0560
5AGT M235T, AGTR1 C573T, ACE I/D, ACE G2350A, CYP11B2 C-344T0.5568 0.0150
6AGT M235T, AGT T174M, AGTR1 C573T, ACE I/D, ACE G2350A, CYP11B2 C-344T0.5290 0.4100
7AGT M235T, AGT T174M, AGTR1 A1166C, AGTR1 C573T, ACE I/D, ACE G2350A, CYP11B2 C-344T0.5227 0.5500

Interactions were validated based on 1000 permutations; CVC: cross-validation consistency.