Gene-Gene Interactions in Renin-Angiotensin-Aldosterone System Contributes to End-Stage Renal Disease Susceptibility in a Han Chinese Population

Table 5

Joint effect of ACE I/D and ACE G2350A from ESRD.

Genotypes	Case	Control	Crude OR (95% CI)	𝑃 value	Adjusted^# OR (95% CI)	𝑃 value^#
I/D
II
G2350A
GG	154	149	1		1
GA	67	103	0.63 (0.43–0.92)	0.017	0.68 (0.46–1.05)	0.084
AA	12	22	0.53 (0.25–1.11)	0.090	0.40 (0.16–1.00)	0.050
ID
G2350A
GG	50	97	0.5 (0.33–0.75)	0.001	0.52 (0.33–0.84)	0.007
GA	221	151	1.42 (1.04–1.92)	0.026	1.56 (1.09–2.22)	0.015
AA	28	28	0.97 (0.55–1.71)	0.910	1.13 (0.58–2.21)	0.715
DD
G2350A
GG	27	35	0.75 (0.43–1.29)	0.297	0.82 (0.43–1.54)	0.536
GA	42	43	0.95 (0.58–1.53)	0.818	1.11 (0.64–1.91)	0.717
AA	46	16	2.78 (1.51–5.13)	0.001	3.13 (1.60–6.13)	0.001

#Adjusted for gender, age, BMI, and smoking status.