Table of Contents Author Guidelines Submit a Manuscript
The Scientific World Journal
Volume 2014, Article ID 173082, 6 pages
Research Article

Bone Mineral Density at Diagnosis of Celiac Disease and after 1 Year of Gluten-Free Diet

1Department of Gastroenterology, Molinette Hospital, University of Turin, 10126 Turin, Italy
2Clinic of Gastroenterology and Hepatology, Via Cavour 31, 10123 Turin, Italy
3Gerontology and Bone Metabolic Disease Section, Molinette Hospital, University of Turin, 10126 Turin, Italy

Received 14 July 2014; Revised 26 August 2014; Accepted 27 August 2014; Published 14 October 2014

Academic Editor: Luigi Maria Larocca

Copyright © 2014 Stefano Pantaleoni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Atypical or silent celiac disease may go undiagnosed for many years and can frequently lead to loss of bone mineral density, with evolution to osteopenia or osteoporosis. The prevalence of the latter conditions, in case of new diagnosis of celiac disease, has been evaluated in many studies but, due to the variability of epidemiologic data and patient features, the results are contradictory. The aim of this study was to evaluate bone mineral density by dual-energy X-ray absorptiometry in 175 consecutive celiac patients at time of diagnosis (169 per-protocol, 23 males, 146 females; average age 38.9 years). Dual-energy X-ray absorptiometry was repeated after 1 year of gluten-free diet in those with T-score value <−1 at diagnosis. Stratification of patients according to sex and age showed a higher prevalence of low bone mineral density in men older than 30 years and in women of all ages. A 1-year gluten-free diet led to a significant improvement in lumbar spine and femoral neck mean T-score value. We propose that dual-energy X-ray absorptiometry should be performed at diagnosis of celiac disease in all women and in male aged >30 years, taking into account each risk factor in single patients.