New Onset of Dermatomyositis/Polymyositis during Anti-TNF-α Therapies: A Systematic Literature Review

Table 2

Characteristics of patients reported regarding diagnostic parameters for antisynthetase syndrome.

Author, year	Antisynthetase antibodies pre-TNF-𝛼	Antisynthetase antibodies after anti-TNF-𝛼	Myositis	ILD	Arthritis	Raynaud’s phenomenon	Fever	Mechanics hand disease
Ishikawa et al., 2011 [24]	NA	Anti-PL-12	Present/PM	Present	Present	Absent	Present	Absent
Ishikawa et al., 2011 [24]	NA	Anti-PL-7	Present/DM	Present	Present	Absent	NA	NA
Ishikawa et al., 2011 [24]	Jo-1	Jo-1	Present/PM	Present	Present	Absent	Absent	Absent
Hall and Zimmermann, 2006 [18]	Negative	Jo-1	Present/DM	Present	Present	Absent	Absent	Absent
Urata et al., 2006 [17]	Jo-1	Jo-1	Present/PM	Present	Present	Absent	Absent	Absent
Musial et al., 2003 [14]	Jo-1	Jo-1	Present/PM	Present	Present	Absent	Present	Absent

ILD: interstitial lung disease, PM: polymyositis, DM: dermatomyositis, NA: not available.