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The Scientific World Journal
Volume 2014 (2014), Article ID 179698, 7 pages
http://dx.doi.org/10.1155/2014/179698
Research Article

Fragile Histidine Triad (FHIT) Suppresses Proliferation and Promotes Apoptosis in Cholangiocarcinoma Cells by Blocking PI3K-Akt Pathway

1Department of General Surgery, Qilu Hospital of Shandong University, No. 107 Wenhuaxi Road, Jinan 250012, China
2Department of General Surgery, Anhui Provincial Hospital Affiliated with Anhui Medical University, Hefei, Anhui 230001, China
3Hepatic-Biliary-Pancreatic Key Laboratory of Anhui Province, Hefei, Anhui 230001, China

Received 2 January 2014; Accepted 17 February 2014; Published 16 March 2014

Academic Editors: G. Bocci and G. Vecchio

Copyright © 2014 Qiang Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

The following is the list of published articles that have cited the current article.

  • Malin Lando, Christina S. Fjeldbo, Saskia M. Wilting, Barbara C Snoek, Eva-Katrine Aarnes, Malin F. Forsberg, Gunnar B. Kristensen, Renske D. M. Steenbergen, and Heidi Lyng, “Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer,” Epigenetics, vol. 10, no. 10, pp. 970–980, 2015. View at Publisher · View at Google Scholar
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  • Wei Yan, Ning Xu, Xiang Han, Xiao-ming Zhou, and Bei He, “The clinicopathological significance of FHIT hypermethylation in non-small cell lung cancer, a meta-analysis and literature review,” Scientific Reports, vol. 6, pp. 19303, 2016. View at Publisher · View at Google Scholar
  • Xiaoyu Wu, Guannan Wu, Xuequan Yao, Gang Hou, and Feng Jiang, “The clinicopathological significance and ethnic difference of FHIT hypermethylation in non-small-cell lung carcinoma: a meta-analysis and literature r,” Drug Design Development And Therapy, vol. 10, pp. 699–709, 2016. View at Publisher · View at Google Scholar
  • Qian Guo, Zhixiang Jian, Baoqing Jia, and Liang Chang, “CXCL7 promotes proliferation and invasion of cholangiocarcinoma cells,” Oncology Reports, vol. 37, no. 2, pp. 1114–1122, 2017. View at Publisher · View at Google Scholar
  • Chengzhen Wu, Ruming Shu, Jie He, and Jun Gao, “The association between RARβ and FHIT promoter methylation and the carcinogenesis of patients with cervical carcinoma: A meta-analysis,” Tumor Biology, vol. 39, no. 6, 2017. View at Publisher · View at Google Scholar
  • Hua-Chuan Zheng, and Li-Li Liu, “FHIT down-regulation was inversely linked to aggressive behaviors and adverse prognosis of gastric cancer: A meta- and bioinformatics analysis,” Oncotarget, vol. 8, no. 64, pp. 108261–108273, 2017. View at Publisher · View at Google Scholar