Research Article

Plasminogen Activator Inhibitor-1 Regulates LPS Induced Inflammation in Rat Macrophages through Autophagy Activation

Figure 2

PAI-1, TNF-α, and IL-1β protein expression in LPS-induced NR8383 cells expressing different levels of PAI-1. Levels of PAI-1 (a, d, g), TNF alpha (b, e, h), and IL-1b (c, f, i) were assessed by ELISA. (a)–(c) Normal NR8383 cells induced with LPS for 2, 4, 8, and 24 h; (d)–(f) control NR8383 cells and cells transfected with PAI-1 siRNA (4 h LPS induction); (g)–(i) control NR8383 cells and cells transfected with the pCDH-PAI-1 plasmid (4 h LPS induction).
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