Research Article
Preliminary Anticonvulsant and Toxicity Screening of Substituted Benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides
Table 1
Physicochemical parameters of the synthesized compounds (5a–t).
| Compound | R | R′ | Molecular formula | | Logb | M.P (°C) | |
| 5a | Cl | H | C17H15ClN4OS | 4.32 | 4.14 | 192–194 | 0.42 | 5b | F | H | C17H15FN4OS | 3.92 | 3.57 | 188–190 | 0.35 | 5c | CH3 | H | C18H18N4OS | 4.24 | 3.92 | 130–132 | 0.81 | 5d | OCH3 | H | C18H18N4O2S | 3.63 | 3.72 | 202–204 | 0.32 | 5e | Cl | 2-OH | C17H15ClN4O2S | 3.93 | 4.73 | 198–200 | 0.59 | 5f | F | 2-OH | C17H15FN4O2S | 3.53 | 3.53 | 164–166 | 0.44 | 5g | CH3 | 2-OH | C18H18N4O2S | 3.86 | 4.46 | 180–182 | 0.61 | 5h | OCH3 | 2-OH | C18H18N4O3S | 3.24 | 4.32 | 110–112 | 0.78 | 5i | Cl | 4-OH | C17H15ClN4O2S | 3.95 | 4.76 | 210–212 | 0.31 | 5j | F | 4-OH | C17H15FN4O2S | 3.59 | 3.61 | 201–203 | 0.48 | 5k | CH3 | 4-OH | C18H18N4O2S | 3.89 | 3.97 | 185–187 | 0.62 | 5l | OCH3 | 4-OH | C18H18N4O3S | 3.24 | 4.32 | 117–119 | 0.57 | 5m | Cl | 4-CH3 | C18H17ClN4OS | 4.8 | 4.61 | 175-176 | 0.65 | 5n | F | 4-CH3 | C18H17FN4OS | 4.44 | 4.06 | 190–192 | 0.4 | 5o | CH3 | 4-CH3 | C19H20N4OS | 4.73 | 4.44 | 205-206 | 0.71 | 5p | OCH3 | 4-CH3 | C19H20N4O2S | 4.12 | 4.22 | 200-201 | 0.6 | 5q | Cl | 4-OCH3 | C18H17ClN4O2S | 4.19 | 4.42 | 140–142 | 0.55 | 5r | F | 4-OCH3 | C18H17FN4O2S | 3.79 | 3.85 | 169–171 | 0.43 | 5s | CH3 | 4-OCH3 | C19H20N4O2S | 4.12 | 4.20 | 161–163 | 0.38 | 5t | OCH3 | 4-OCH3 | C19H20N4O3S | 4.75 | 4.41 | 215–217 | 0.54 |
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Solvent of crystallization-ethanol. was calculated using octanol-phosphate buffer. Log was calculated using software chem. Draw ultra 8. cSolvent system-toluene : ethyl acetate : formic acid (5 : 4 : 1), benzene : acetone (8 : 2).
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