Preliminary Anticonvulsant and Toxicity Screening of Substituted Benzylidenehydrazinyl-N-(6-substituted benzo[d]thiazol-2-yl)propanamides

Table 4

Phase III quantitative toxicity profile of selected compounds.

Compound			HD50/ED50
			MES	PTZ
5h	642.2 (609.7–689.6)^c	865.9 (821.1–902.7)	23.01	3.41
5p	712.3 (664.9–768.2)	650.5 (609.1–697.5)	25.07	8.00
PHY	182.4 (169.3–94.2)	224.8 (201.3–249.2)	19.15	>0.06

Median hypnotic dose in mg/kg; ^bmedian lethal dose in mg/kg; mortality was determined 24 h after i.p. injection.
^c95% confidence interval in parenthesis.