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The Scientific World Journal
Volume 2014, Article ID 196513, 7 pages
Research Article

The Limbic Degradation of Aging Brain: A Quantitative Analysis with Diffusion Tensor Imaging

1Radiology Department, Ondokuz Mayıs University, Kurupelit, 55139 Samsun, Turkey
2Radiology Department, Ataturk Research and Education Hospital, Ankara, Turkey
3Radiology Department, Medipol University Hospital, Istanbul, Turkey
4Radiology Department, Adıyaman University, Adıyaman, Turkey

Received 5 February 2014; Revised 2 March 2014; Accepted 3 March 2014; Published 13 April 2014

Academic Editor: Bernhard Schaller

Copyright © 2014 Hediye Pınar Gunbey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. The limbic system primarily responsible for our emotional life and memories is known to undergo degradation with aging and diffusion tensor imaging (DTI) is capable of revealing the white matter integrity. The aim of this study is to investigate age-related changes of quantitative diffusivity parameters and fiber characteristics on limbic system in healthy volunteers. Methods. 31 healthy subjects aged 25–70 years were examined at 1,5 TMR. Quantitative fiber tracking was performed of fornix, cingulum, and the parahippocampal gyrus. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measurements of bilateral hippocampus, amygdala, fornix, cingulum, and parahippocampal gyrus were obtained as related components. Results. The FA values of left hippocampus, bilateral parahippocampal gyrus, and fornix showed negative correlations with aging. The ADC values of right amygdala and left cingulum interestingly showed negative relation and the left hippocampus represented positive relation with age. The cingulum showed no correlation. The significant relative changes per decade of age were found in the cingulum and parahippocampal gyrus FA measurements. Conclusion. Our approach shows that aging affects hippocampus, parahippocampus, and fornix significantly but not cingulum. These findings reveal age-related changes of limbic system in normal population that may contribute to future DTI studies.