TY - JOUR A2 - Sánchez-Margalet, Víctor AU - Salleh, Naguib AU - Giribabu, Nelli PY - 2014 DA - 2014/07/24 TI - Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception SP - 201514 VL - 2014 AB - Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception. SN - 2356-6140 UR - https://doi.org/10.1155/2014/201514 DO - 10.1155/2014/201514 JF - The Scientific World Journal PB - Hindawi Publishing Corporation KW - ER -