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The Scientific World Journal
Volume 2014 (2014), Article ID 201514, 10 pages
Review Article

Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 1 April 2014; Accepted 9 June 2014; Published 24 July 2014

Academic Editor: Víctor Sánchez-Margalet

Copyright © 2014 Naguib Salleh and Nelli Giribabu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.