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The Scientific World Journal
Volume 2014, Article ID 217039, 6 pages
http://dx.doi.org/10.1155/2014/217039
Research Article

Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile

1Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, Russia
2Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Russia
3Institute of Biology, Taras Shevchenko National University of Kyiv, Kyiv 03022, Ukraine

Received 9 August 2013; Accepted 25 December 2013; Published 9 February 2014

Academic Editors: T. Chiba and E. Scarpellini

Copyright © 2014 Konstantin V. Kudryavtsev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluated in vivo at water immersion restraint conditions. The levels of lipid peroxidation products and activities of antioxidative system enzymes were measured in gastric mucosa and correlated with the observed gastroprotective activity of the active compounds. Prophylactic single-dose 1 mg/kg treatment with (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline efficiently decreases up to 86% stress-induced stomach ulceration in rats. Discovered small-molecule antiulcer agents modulate activities of gastric mucosa tissue superoxide dismutase, catalase, and xanthine oxidase in concerted directions. Gastroprotective effect of (2-hydroxyphenyl)thioacetyl derivatives of L-lysine and L-proline at least partially depends on the correction of gastric mucosa oxidative balance.