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The Scientific World Journal
Volume 2014 (2014), Article ID 217142, 4 pages
http://dx.doi.org/10.1155/2014/217142
Research Article

Pharmacokinetics and Biodistribution of Zinc-Enriched Yeast in Rats

1Division of Nutrition and Health, Angel Yeast Co. Ltd., 168 Chengdong Avenue, Yichang 443003, China
2Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Received 21 July 2014; Revised 3 August 2014; Accepted 7 August 2014; Published 17 August 2014

Academic Editor: Feng Sun

Copyright © 2014 Shuangqing Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Zinc-enriched yeast (ZnY) and zinc sulfate (ZnSO4) are considered zinc (Zn) supplements currently available. The purpose of the investigation was to compare and evaluate pharmacokinetics and biodistribution of ZnY and ZnSO4 in rats. ZnY or ZnSO4 were orally administered to rats at a single dose of 4 mg Zn/kg and Zn levels in plasma and various tissues were determined using inductively coupled plasma-optical emission spectrometry. Maximum plasma concentration values were 3.87 and 2.81 μg/mL for ZnY and ZnSO4, respectively. Both ZnY and ZnSO4 were slowly eliminated with a half-life of over 7 h and bone had the highest Zn level in all tissues. Compared to ZnSO4, the relative bioavailability of ZnY was 138.4%, indicating that ZnY had a significantly higher bioavailability than ZnSO4.