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The Scientific World Journal
Volume 2014, Article ID 217525, 7 pages
Research Article

A Chinese Herbal Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats

1Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan
2Department of Pharmacy, Taipei Medical University Hospital, No. 252, Wuxing Street, Xinyi District, Taipei 110, Taiwan
3Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, No. 111, Section 3, Xinglong Road, Wenshan District, Taipei 116, Taiwan
4Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan
5Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, No. 100, Shiquan 1st Road, Sanmin District, Kaohsiung 807, Taiwan
6Cancer Center, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan
7Food and Drug Administration, Ministry of Health and Welfare, No. 161-2, Kunyang Street, Nangang District, Taipei 115, Taiwan
8Department of Healthcare Management, Yuanpei University, No. 306, Yuanpei Street, Hsinchu 300, Taiwan
9Department of Early Childhood Care and Education, Kang-Ning Junior College of Medical Care and Management, No. 137, Lane 75, Section 3, Kangning Road, Neihu District, Taipei 114, Taiwan
10Department of Nursing, School of Medicine, National Taiwan University, No. 1, Section 1, Jen Ai Road, Zhongzheng District, Taipei 100, Taiwan
11Department of Nursing, Ching-Kuo Institute of Management and Health, No. 336, Fu-Hsing Road, Zhongshan District, Keelung 203, Taiwan
12Department of Health Industry Management, School of Health Care Management, Kainan University, No. 1, Kainan Road, Luzhu Shiang, Taoyuan 338, Taiwan

Received 7 April 2014; Revised 12 May 2014; Accepted 12 May 2014; Published 3 June 2014

Academic Editor: Li-Yeh Chuang

Copyright © 2014 Shu-Chen Chien et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied. The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN-) induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects. After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were significantly elevated, whereas the albumin level decreased. Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated. In addition, JWXYS treatment prevented liver fibrosis induced by DMN. JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats. Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury. The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.