TY - JOUR
A2 - Montuori, N.
A2 - Iaccarino, G.
A2 - Illario, M.
AU - Ma, Hong
AU - You, Guo-Ping
AU - Zhang, Xuan-Pu
AU - Yang, Xiang-Jiu
AU - Lu, Hua-Dong
AU - Huang, Yan-Ling
AU - Zhang, Wen-Qiang
PY - 2014
DA - 2014/02/06
TI - A Novel Role of Globular Adiponectin in Treatment with HFD/STZ Induced T2DM Combined with NAFLD Rats
SP - 230835
VL - 2014
AB - Aims. To evaluate the effects of globular adiponectin (gAd) on treatment of type 2 diabetic rats combined with NAFLD. Materials and Methods. Twenty-one male wistar rats were fed with normal diet (7 rats) or high fat diet (HFD) (14 rats) for 4 weeks, and then HFD-fed rats were injected with streptozotocin (STZ) to induce type 2 diabetes mellitus (T2DM). Half of T2DM rats were randomly injected with gAd intraperitoneally for 7 days. The expressions of adiponectin receptors (adipoR1/R2) in liver and skeletal muscle tissues were detected through western blotting or RT-qPCR, respectively. Results. Globular adiponectin alleviated the hepatic steatosis and increased insulin secretion. In liver, both the protein and mRNA expressions of adipoR2 in T2DM group decreased (P<0.05, resp.) in contrast to NC group and increased (P<0.05 and P<0.001, resp.) after gAd treatment. But the protein and mRNA expressions of adipoR1 increased (P<0.05, resp.) in T2DM group and no change was found in the gAd-treated group. In skeletal muscle, the protein and mRNA expressions of adipoR1 and adipoR2 were upregulated in T2DM group and were downregulated after gAd treatment. Conclusions. Globular adiponectin could ameliorate the hepatic steatosis and vary the expressions of adiponectin receptors in liver and skeletal muscle by stimulating insulin secretion.
SN - 2356-6140
UR - https://doi.org/10.1155/2014/230835
DO - 10.1155/2014/230835
JF - The Scientific World Journal
PB - Hindawi Publishing Corporation
KW -
ER -