Gossypol Toxicity from Cottonseed Products

Table 1

Experimental studies showing liver damage induced by gossypol.

Animals	Gossypol dose	Route of administration	Duration of treatment	Reference
Broiler	0.4% of total gossypol in food	Oral	20 days	[11]
Chickens	0.1% of free gossypol in food	Oral	21 days	[44]
Rats	25 mg/kg BW	Intraperitoneal	Single dose	[45]
Rats	30 mg/kg BW	Intraperitoneal	Single dose	[46]
Rats	5, 10 and 20 mg/kg BW	Intraperitoneal	10 days	[47]