Gossypol Toxicity from Cottonseed Products

Table 2

Selected experimental studies describing effects of gossypol on male reproduction.

Animals	Gossypol dose	Effects	Reference
Hamsters	10 mg/kg BW/day	Degeneration of spermatocytes	[48]
Rats	20 mg/kg BW/day	Degeneration of spermatocytes	[48]
Mice	40 mg/kg BW/day	No degeneration	[48]
Rats	25 mg/kg BW/day	Decreased spermatogenesis, Sertoli cell, and seminiferous tubules damage	[49]
Rats	10 mg/kg BW/day	Tubular degeneration, reduced testosterone concentrations, and involutions of ventral prostate and seminal vesicles	[50]
Rats	5, 10 and 20 mg/kg BW/day	Decreased sperm count and motility, increased abnormal sperm count, and reduced serum levels of testosterone, LH, and FSH	[47]
Bulls	16.4 mg/kg BW/day	Reduced sperm production and motility and increased proportion of sperm midpiece abnormalities	[51]
Bulls	8 mg/kg BW/day	Primary and secondary sperm abnormalities and increased number of sperm with proximal droplets	[52]