Evaluation of Lung and Bronchoalveolar Lavage Fluid Oxidative Stress Indices for Assessing the Preventing Effects of Safranal on Respiratory Distress in Diabetic Rats

Table 1

GSH, MDA, SOD, CAT, and NO in BALF of control (C), diabetic (D), diabetic + (0.25 mg/kg/day) safranal-treated (D + S1), diabetic + (0.5 mg/kg/day) safranal-treated (D + S2), and diabetic + (0.75 mg/kg/day) safranal-treated (D + S3) rats following 4 weeks of study.

BALF	C	D	D + S1	D + S2	D + S3
MDA (nmol/mg protein)	0.74±0.10	2.08±0.12^∗∗∗	1.68±0.10^∗∗∗	1.52±0.15^∗∗,+	0.88±0.13^+++,##,×
GSH (nmol/mg protein)	2.38±0.21	0.46±0.10^∗∗∗	1.36±0.12^∗∗,++	1.82±0.12^+++	2.32±0.17^+++,##
SOD (U/mg protein)	4.70±0.51	1.54±0.27^∗∗∗	3.26±0.30^∗∗,+	4.00±0.30^∗,+++	4.80±0.25^+++,#
CAT (U/mg protein)	2.24±0.20	0.44±0.12^∗∗∗	1.12±0.12^∗∗∗,+	1.84±0.13^+++,#	2.14±0.11^+++,###
NO (μmol/L)	1.98±0.71	13.08±1.08^∗∗∗	10.02±0.71^∗∗∗,+	6.80±0.64^∗,+++,#	3.00±0.57^+++,###,×

Each measurement has been done at least in triplicate and the values are the means ± SEM for eight rats in each group.
Statistical significance for the difference between the data of control versus other groups: ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001.
Statistical significance for the difference between the data of diabetes versus treated groups: ⁺⁺𝑃<0.01, ⁺⁺𝑃<0.01, ⁺⁺⁺𝑃<0.001.
Statistical significance for the difference between the data D + S1 versus D + S2 and D + S3 (^#𝑃<0.05,^##𝑃<0.01, ^###𝑃<0.001).
Statistical significance for the difference between the data between D + S2 versus D + S3 (^×𝑃<0.05).