Assessment of Cellular Responses after Short- and Long-Term Exposure to Silver Nanoparticles in Human Neuroblastoma (SH-SY5Y) and Astrocytoma (D384) Cells
Figure 1
Mitochondrial function evaluation by MTT assay in SH-SY5Y, D384, and 549 cell lines. Evaluation of mitochondrial function in SH-SY5Y, D384, and A549 cell lines after 4 h (a), 24 h (b), and 48 h (c) exposure to increasing concentrations (from 1 to 100 μg/mL) of AgNPs showed dose- and time-dependent changes in mitochondrial metabolism on both cerebral cell lines starting at the dose of 25 μg/mL and already after 4 h exposure. Pulmonary cells (A549) were less susceptible to AgNP exposure, showing a reduction of cell viability after 48 h exposure at the higher doses of AgNPs. *Different from control in each cell line , Statistical analysis by ANOVA followed by Tukey’s test. Error bars indicate S.D.
