PCL/PHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride

Table 1

Composition of manidipine-loaded and unloaded PCL/PHBV microparticles.

Formulation	PCL-M0	PCL-M5	PCL-M10	PHBV-M0	PHBV-M5	PHBV-M10
Organic
MAN (g)	—	0.1	0.2	—	0.1	0.2
PCL (g)	2.0	1.9	1.8	—	—	—
PHBV (g)	—	—	—	2.0	1.9	1.8
Dichloromethane (mL)	40	40	40	—	—	—
Chloroform (mL)	—	—	—	40	40	40
Aqueous
2% PVA solution (mL)	200	200	200	200	200	200
Polysorbate 80 (g)	0.25	0.25	0.25	0.25	0.25	0.25
NaOH 0.1 M (mL)	2	2	2	—	—	—