Research Article

PCL/PHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride

Table 2

Mathematical models applied to dissolution experiments.

ModelEquation

Dissolution efficiency
First-order
Biexponential
Zero-order
Weibull
Monolag

: dissolved percentage; : shape parameter; TD: time interval necessary to release 63.2% of the drug; , , and : kinetics constants; : dissolution time; and : initial drug concentrations that contribute for the two dissolution stages.