Identification of Levothyroxine Antichagasic Activity through Computer-Aided Drug Repurposing
Figure 6
(a) Inhibitory effect of the three selected candidates on purified Cz activity. The final concentration of each compound was 50 μM. Protease activity is expressed as percentage of the control condition (2% DMSO). (b) Dose-dependent inhibitory effect of levothyroxine on purified Cz activity. Levothyroxine was assayed in a concentration range of 0–200 μM. Remanent Cz activity was expressed as a percentage respect to the control (0 μM levothyroxine, 2% DMSO). Asterisks indicate significant differences (*).
