Preparation and Evaluation of Novel In Situ Gels Containing Acyclovir for the Treatment of Oral Herpes Simplex Virus Infections

Table 1

Composition of the drug loaded formulations containing tween 80 and ethanol.

FC	Drug (gm)	T + E (mL)	P407 (gm)	P188 (gm)	C934 (gm)	HPMC K-100 (gm)	MP (gm)	PP (gm)	D/W (mL)
Ft1	0.6	6	6	—	—	0.15	0.03	0.003	30
Ft2	0.6	6	4	2	—	0.15	0.03	0.003	30
Ft3	0.6	6	4.5	—	0.09	0.15	0.03	0.003	30
Ft4	0.6	6	6	—	0.03	0.15	0.03	0.003	30
Ft5	0.6	6	6	—	0.09	0.15	0.03	0.003	30
Ft6	0.6	6	6	—	0.15	0.15	0.03	0.003	30

Note: FC: formulation code, T: tween 80, E: ethanol, P407: poloxamer407, P188: poloxamer188, C934: carbopol934, HPMC K-100: hydroxypropyl methyl cellulose, MP: methyl paraben, PP: propyl paraben, and D/W: distilled water.