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The Scientific World Journal
Volume 2014 (2014), Article ID 312704, 7 pages
Research Article

Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population

1Department of Digestive Diseases, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China
2Department of Immunology of Shanghai Medical School and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
3Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
4Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

Received 23 March 2014; Revised 6 July 2014; Accepted 21 July 2014; Published 7 August 2014

Academic Editor: Manuela Ferracin

Copyright © 2014 Rui Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Single-nucleotide polymorphisms in microRNAs play important roles in oncogenesis and cancer development. Objective. We aim to explore whether miR-646 rs6513497 is associated with the risk of hepatocellular carcinoma. Methods. Total 997 HCC patients and 993 cancer-free controls were enrolled in this study. Genotyping was performed using MassARRAY method. Results. Compared with the T allele of rs6513497, the G allele was associated with a significantly decreased risk of HCC (OR = 0.788, 95% CI = 0.631–0.985, P = 0.037); moreover, a more protective effect of the G allele was shown in males (OR = 0.695, 95% CI = 0.539–0.897, P = 0.005 in HCC and OR = 0.739, 95% CI = 0.562–0.972, P = 0.030 in HBV-related HCC), basically in a dominant manner (HCC: OR = 0.681, 95% CI = 0.162–0.896, P = 0.006; HBV-related HCC: OR = 0.715, 95% CI = 0.532–0.962, P = 0.027). Conclusions. Our findings support the view that the miR-646 SNP rs6513497 may contribute to the susceptibility of HCC.