Association between a Variant in MicroRNA-646 and the Susceptibility to Hepatocellular Carcinoma in a Large-Scale Population

Table 1

General characteristics in hepatocellular carcinoma patients and controls.

	Cases ( = 997)	Controls ( = 993)	value
	Number (%) or mean ± SD	Number (%) or mean ± SD
Age (years)	54.70 ± 11.27	59.57 ± 11.65	<0.001*
Gender
Male	819 (82.1)	721 (72.6)	<0.001*
Female	178 (17.9)	272 (27.4)
Smoking status
Never	665 (67.6)	527 (53.1)	<0.001*
Ever	319 (32.4)	466 (46.9)
Drinking status
Never	734 (74.4)	732 (73.7)	0.712
Ever	252 (25.6)	261 (26.3)
HBsAg ( = 951)
Negative	180 (18.9)
Positive	771 (81.1)
Tumor size ( = 540)
<5 cm	218 (40.4)
≥5 cm	322 (59.6)
Tumor number ( = 539)
Single	475 (88.1)
Multiple	64 (11.9)
Tumor grade ( = 385)
I-II	84 (21.8)
III-IV	301 (78.2)
Serum level of tumor markers
ALT (U/L, in 989 subjects)	58.29 ± 86.04
AST (U/L, in 985 subjects)	62.24 ± 81.06
AFP
<20 ug/L	363 (37.2)
≥20 ug/L	612 (62.8)
(ug/L, in 404 subjects)	126.87 ± 289.61 (0.6–1210)
HBV-DNA (IU/mL, in 450 subjects)	()

value less than 0.05.