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The Scientific World Journal
Volume 2014, Article ID 313609, 13 pages
Research Article

UV Spectrophotometric Simultaneous Determination of Paracetamol and Ibuprofen in Combined Tablets by Derivative and Wavelet Transforms

1Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam
2College of Education-Gia Lai, 126 Le Thanh Ton, Pleiku, Gia Lai, Vietnam
3Center for Computational Science and Faculty of Chemistry, Hanoi National University of Education, Hanoi, Vietnam

Received 31 August 2013; Accepted 31 October 2013; Published 19 February 2014

Academic Editors: C. Pistos and Y. Roggo

Copyright © 2014 Vu Dang Hoang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The application of first-order derivative and wavelet transforms to UV spectra and ratio spectra was proposed for the simultaneous determination of ibuprofen and paracetamol in their combined tablets. A new hybrid approach on the combined use of first-order derivative and wavelet transforms to spectra was also discussed. In this application, DWT (sym6 and haar), CWT (mexh), and FWT were optimized to give the highest spectral recoveries. Calibration graphs in the linear concentration ranges of ibuprofen (12–32 mg/L) and paracetamol (20–40 mg/L) were obtained by measuring the amplitudes of the transformed signals. Our proposed spectrophotometric methods were statistically compared to HPLC in terms of precision and accuracy.