Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria

Table 1

Antiproliferative activity [IC₅₀ values (µg/mL)] and selectivity index of crude and fractionated extracts of Curcuma zedoaria against human cancer and noncancer (HUVEC) cell lines.

Extracts	IC50 (µg/mL)^a
	MCF-7	SI^b	Ca Ski	SI^b	HUVEC
Hexane	18.4 ± 1.6	5.4	19.0 ± 1.5	5.3	>100.0
Dichloromethane	40.6 ± 2.3	2.5	83.5 ± 2.7	1.2	>100.0
Ethyl acetate	>100.0	1.0	>100.0	1.0	>100.0
Methanol	>100.0	1.0	>100.0	1.0	>100.0
Methanol (soxhlet extraction)	>100.0	1.0	>100.0	1.0	>100.0

aData are presented as mean ± standard deviation (SD) of three replicates.
^bSI is the selectivity index. SI values ≥3.0 denote high selectivity towards cancerous cells.