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The Scientific World Journal
Volume 2014 (2014), Article ID 340271, 9 pages
http://dx.doi.org/10.1155/2014/340271
Research Article

Radixin Enhances Colon Cancer Cell Invasion by Increasing MMP-7 Production via Rac1-ERK Pathway

Department of Gastroenterology, Pu’ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, 50 Gu Tian San Road, Wuhan 430034, China

Received 24 February 2014; Revised 7 June 2014; Accepted 13 June 2014; Published 21 July 2014

Academic Editor: Konstantin G. Birukov

Copyright © 2014 Qi-Hong Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

As a member of the ezrin-radixin-moesin (ERM) family, radixin is overexpressed in many tumor tissues. However, little is known about its role in the progression of colon cancer. So we here aimed to determine the function of radixin in colon cancer cell invasion. Interestingly, we found that the expression of radixin was significantly elevated in colon cancer cells. Knockdown of radixin suppressed the invasion and migration of colon cancer cells. Further, knockdown of radixin inhibited the activation of Rac1 and ERK1/2, and decreased the expression and secretion of MMP-7. In addition, Rac1-ERK signaling pathway was required for the radixin-promoted invasion and MMP-7 production. Together, our findings suggest that radixin enhances the invasion and migration of colon cancer cells. Activation of Rac1-ERK pathway and consequent upregulation of MMP-7 production may contribute to the function of radixin in the regulation of colon cancer cell invasion. Thus, radixin may act as a novel target for the diagnosis and treatment of colon cancer.