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The Scientific World Journal
Volume 2014 (2014), Article ID 347813, 6 pages
http://dx.doi.org/10.1155/2014/347813
Research Article

Enoxaparin Prevents Steroid-Related Avascular Necrosis of the Femoral Head

1Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
2Department of Oral and Maxillofacial Surgery, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany
3Department of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany
4Department of Orthopedic and Trauma Surgery, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany
5Department of Orthopaedic and Spine Surgery, AGAPLESION EV. BATHILDISKRANKENHAUS gemeinnützige GmbH, Maulbeerallee 4, 31812 Bad Pyrmont, Germany

Received 19 February 2014; Revised 6 June 2014; Accepted 11 June 2014; Published 2 July 2014

Academic Editor: Anastasios V. Korompilias

Copyright © 2014 Rainer Beckmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. Mont, L. C. Jones, and D. S. Hungerford, “Current concepts review—nontraumatic osteonecrosis of the femoral head: ten years later,” Journal of Bone and Joint Surgery A, vol. 88, no. 5, pp. 1117–1132, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. M. A. Mont and D. S. Hungerford, “Non-traumatic avascular necrosis of the femoral head,” Journal of Bone and Joint Surgery A, vol. 77, no. 3, pp. 459–474, 1995. View at Google Scholar · View at Scopus
  3. P. Orth and K. Anagnostakos, “Coagulation abnormalities in osteonecrosis and bone marrow edema syndrome,” Orthopedics, vol. 36, no. 4, pp. 290–300, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Motomura, T. Yamamoto, K. Miyanishi, A. Yamashita, K. Sueishi, and Y. Iwamoto, “Bone marrow fat-cell enlargement in early steroid-induced osteonecrosis—a histomorphometric study of autopsy cases,” Pathology Research and Practice, vol. 200, no. 11-12, pp. 807–811, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. C. J. Glueck, R. Freiberg, T. Tracy, D. Stroop, and P. Wang, “Thrombophilia and hypofibrinolysis: Pathophysiologies of osteonecrosis,” Clinical Orthopaedics and Related Research, no. 334, pp. 43–56, 1997. View at Google Scholar · View at Scopus
  6. L. Yang, K. Boyd, S. C. Kaste, L. Kamdem, R. J. Rahija, and M. V. Relling, “A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday,” Journal of Orthopaedic Research, vol. 27, no. 2, pp. 169–175, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. C. J. Glueck, R. A. Freiberg, L. Sieve, and P. Wang, “Enoxaparin prevents progression of stages I and II osteonecrosis of the hip,” Clinical Orthopaedics and Related Research, no. 435, pp. 164–170, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Bejar, E. Peled, and J. H. Boss, “Vasculature deprivation—induced osteonecrosis of the rat femoral head as a model for therapeutic trials,” Theoretical Biology and Medical Modelling, vol. 2, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. J. H. Boss and I. Misselevich, “Osteonecrosis of the femoral head of laboratory animals: the lessons learned from a comparative study of osteonecrosis in man and experimental animals,” Veterinary Pathology, vol. 40, no. 4, pp. 345–354, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Jia, W. Yao, M. Guan et al., “Glucocorticoid dose determines osteocyte cell fate,” The FASEB Journal, vol. 25, no. 10, pp. 3366–3376, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Yamamoto, T. Irisa, Y. Sugioka, and K. Sueishi, “Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits,” Arthritis and Rheumatism, vol. 40, no. 11, pp. 2055–2064, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. C. H. Kemper, J. W. Baggenstoss, and A. H. Slocumb, “The relationship of therapy with cortisone to the incidence of vascular lesions in rheumatoid arthritis,” Annals of Internal Medicine, vol. 46, no. 5, pp. 831–851, 1957. View at Publisher · View at Google Scholar
  13. T. Masada, K. Iwakiri, Y. Oda et al., “Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model,” Journal of Orthopaedic Research, vol. 26, no. 1, pp. 91–95, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Yang and L. Zhang, “Glucocorticoids and vascular reactivity,” Current Vascular Pharmacology, vol. 2, no. 1, pp. 1–12, 2004. View at Google Scholar
  15. T. Yamamoto, E. F. DiCarlo, and P. G. Bullough, “The prevalence and clinicopathological appearance of extension of osteonecrosis in the femoral head,” The Journal of Bone and Joint Surgery B, vol. 81, no. 2, pp. 328–332, 1999. View at Google Scholar · View at Scopus
  16. J. Seamon, T. Keller, J. Saleh, and Q. Cui, “The pathogenesis of nontraumatic osteonecrosis,” Arthritis, vol. 2012, Article ID 601763, 11 pages, 2012. View at Publisher · View at Google Scholar
  17. C. J. Glueck, R. Freiberg, T. Tracy, D. Stroop, and P. Wang, “Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis,” Clinical Orthopaedics and Related Research, no. 334, pp. 43–56, 1997. View at Google Scholar · View at Scopus
  18. C. Glueck, R. Freiberg, and G. Boriel, “The role of the factor V leiden mutation in osteonecrosis of the hip,” Clinical and Applied Thrombosis/Hemostasis, vol. 19, no. 5, pp. 499–503, 2013. View at Publisher · View at Google Scholar
  19. M. G. Lykissas, I. D. Gelalis, I. P. Kostas-Agnantis, G. Vozonelos, and A. V. Korompilias, “The role of hypercoagulability in the development of osteonecrosis of the femoral head,” Orthopedic Reviews, vol. 4, no. 2, article e17, 2012. View at Google Scholar
  20. W. Drescher, K. P. Weigert, M. H. Bünger, J. Ingerslev, C. Bünger, and E. S. Hansen, “Femoral head blood flow reduction and hypercoagulability under 24 h megadose steroid treatment in pigs,” Journal of Orthopaedic Research, vol. 22, no. 3, pp. 501–508, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Kerachian, D. Cournoyer, E. J. Harvey et al., “New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model,” Arthritis Research and Therapy, vol. 12, no. 3, article R124, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. R. W. Wu, F. S. Wang, J. Y. Ko, C. J. Wang, and S. Wu, “Comparative serum proteome expression of osteonecrosis of the femoral head in adults,” Bone, vol. 43, no. 3, pp. 561–566, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. M. L. te Winkel, I. M. Appel, R. Pieters, and M. M. van den Heuvel-Eibrink, “Impaired dexamethasone-related increase of anticoagulants is associated with the development of osteonecrosis in childhood acute lymphoblastic leukemia,” Haematologica, vol. 93, no. 10, pp. 1570–1574, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Cenni, C. Fotia, E. Rustemi et al., “Idiopathic and secondary osteonecrosis of the femoral head show different thrombophilic changes and normal or higher levels of platelet growth factors,” Acta Orthopaedica, vol. 82, no. 1, pp. 42–49, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. R. J. Sebaldt, J. R. Sheller, J. A. Oates, L. J. Roberts II, and G. A. Fitzgerald, “Inhibition of eicosanoid biosynthesis by glucocorticoids in humans,” Proceedings of the National Academy of Sciences of the United States of America, vol. 87, no. 18, pp. 6974–6978, 1990. View at Publisher · View at Google Scholar · View at Scopus
  26. J. P. Jones Jr., “Fat embolism and osteonecrosis,” Orthopedic Clinics of North America, vol. 16, no. 4, pp. 595–633, 1985. View at Google Scholar · View at Scopus
  27. S. Masuko and R. J. Linhardt, “Chemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics,” Future Medicinal Chemistry, vol. 4, no. 3, pp. 289–296, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Manduteanu, M. Voinea, M. Capraru, E. Dragomir, and M. Simionescu, “A novel attribute of enoxaparin: inhibition of monocyte adhesion to endothelial cells by a mechanism involving cell adhesion molecules,” Pharmacology, vol. 65, no. 1, pp. 32–37, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Giannini, S. Nobile, and M. Sartori, “Organ transplantation and glucocorticoid-induced osteoporosis,” in Glucocorticoid-Induced Osteoporosis, A. Giustina, A. Angeli, and E. Canalis, Eds., Karger, Basel, Switzerland, 2002. View at Google Scholar