The Scientific World Journal / 2014 / Article / Tab 1

Research Article

Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides

Table 1

Anticonvulsant potential and neurotoxicity of the target compounds 6a–p.

Compound no. Dosea (μmol/kg)Anticonvulsant activity (% protection)Neurotoxicityb
scPTZMES

6a750160/6
6b6675066c0/6
6c680502/6
6d718100160/6
6e71883500/6
6f684100c0/6
6g972500/6
6h6168316c0/6
6i64510016c0/6
6j58666160/6
6k52050161/6
6l81810016c0/6
6m56516162/6
6n814100c0/6
6o66266160/6
6p636100c0/6
Phenytoin159100ND
Phenobarbitone108100ND

Doses were administered i.p. bRotarod test: number of animals exhibiting toxicity/number of animals tested.
cAdministered dose was 250 mg/kg. Animals ( ) were examined at 0.5 hr after administration of the test compounds. The dash (—) indicates an absence of anticonvulsant activity at the administered dose. ND: Not determined. The figures in the table indicate the dose whereby the best % protection from seizures was demonstrated.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.