Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides

Table 1

Anticonvulsant potential and neurotoxicity of the target compounds 6a–p.

Compound no.	Dose^a (μmol/kg)	Anticonvulsant activity (% protection)		Neurotoxicity^b
		scPTZ	MES
6a	750	16	—	0/6
6b	667	50	66^c	0/6
6c	680	50	—	2/6
6d	718	100	16	0/6
6e	718	83	50	0/6
6f	684	100	—^c	0/6
6g	972	50	—	0/6
6h	616	83	16^c	0/6
6i	645	100	16^c	0/6
6j	586	66	16	0/6
6k	520	50	16	1/6
6l	818	100	16^c	0/6
6m	565	16	16	2/6
6n	814	100	—^c	0/6
6o	662	66	16	0/6
6p	636	100	—^c	0/6
Phenytoin	159	—	100	ND
Phenobarbitone	108	100	—	ND

aDoses were administered i.p. ^bRotarod test: number of animals exhibiting toxicity/number of animals tested.
^cAdministered dose was 250 mg/kg. Animals (𝑛=6) were examined at 0.5 hr after administration of the test compounds. The dash (—) indicates an absence of anticonvulsant activity at the administered dose. ND: Not determined. The figures in the table indicate the dose whereby the best % protection from seizures was demonstrated.