Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage

Figure 2

PCA pretreatment improved intestinal I/R-induced liver histopathologic injury. Tissues were harvested at the end of reperfusion and were stained with hematoxylin eosin. Slides were examined under light microscopy at 200x magnification, bars = 50 μm. Histologic injury scores in groups were quantified. Results are presented as the mean ± SD, 𝑛=10. **𝑃<0.01 versus sham group; ^#𝑃<0.05 versus I/R group; ^##𝑃<0.01 versus I/R group.