Development of a Highly Biocompatible Antituberculosis Nanodelivery Formulation Based on Para-Aminosalicylic Acid—Zinc Layered Hydroxide Nanocomposites

Table 3

Rate constant (𝑘) and correlation coefficient 𝑅² determined from the release kinetics of PAS from PAS-ZLH (nanocomposite-A) into PBS solutions of pH 7.4 and pH 4.8.

Samples	pH	Release/%	𝑅^2			Pseudo-second order
	—	—	Pseudo-first order	Pseudo-second order	Parabolic diffusion model	Rate constant 𝐾2 (mg/min)
Nanocomposite-A
PAS-ZLLH	4.8	99	0.56	0.99	0.66	2.85 × 10^−4
PAS-ZLLH	7.4	94	0.81	0.99	0.95	2.70 × 10^−5

Of PAS are similar to the nanocomposite-B as reported previously by us [7].