Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia
Figure 4
Effects of chronic administration of 8-OH-DPAT. (a) Locomotor activity in the open-field. Chronic 8-OH-DPAT treatment had no effect on the sham rats but significantly reduced the locomotor activity in the OB rats (). (b) Radiant heat pain threshold. Pain thresholds in the sham rats were increased after the treatment; by contrast, those in the OB rats were decreased and restored to normal level (). Data are presented as mean ± SEM. *.05, ***.