Research Article

Chronic Administration of 5-HT1A Receptor Agonist Relieves Depression and Depression-Induced Hypoalgesia

Figure 4

Effects of chronic administration of 8-OH-DPAT. (a) Locomotor activity in the open-field. Chronic 8-OH-DPAT treatment had no effect on the sham rats but significantly reduced the locomotor activity in the OB rats ( ). (b) Radiant heat pain threshold. Pain thresholds in the sham rats were increased after the treatment; by contrast, those in the OB rats were decreased and restored to normal level ( ). Data are presented as mean ± SEM. * .05, *** .
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(a)
405736.fig.004b
(b)