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The Scientific World Journal
Volume 2014, Article ID 406921, 6 pages
http://dx.doi.org/10.1155/2014/406921
Research Article

An Assessment of Wound Healing Potential of Argyreia speciosa Leaves

1Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants, (CIMAP), Lucknow 226 015, India
2Analytical Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, (CIMAP), Lucknow 226 015, India
3Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India

Received 31 August 2013; Accepted 30 October 2013; Published 29 January 2014

Academic Editors: C. M. Davis, E. Hopper-Borge, Z. Ma, and K. H. Nguyen

Copyright © 2014 Kuldeep Singh Yadav et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In North India, poultice of young unfolded leaves of Argyreia speciosa Linn. (Convolvulaceae) is used for healing wounds. In order to find scientific evidence for the traditional utilization of leaves of A. speciosa in wound healing, this investigation was carried out. A linear incision wound of about 3 cm in length and 2 mm in depth and circular excision wound of 177 mm2 full thickness were made on the dorsal region of separate groups () of anesthetized Swiss albino mice. A simple ointment, developed by including ethanol, ethanol-water, and water extracts (10% each, separately) of A. speciosa, was applied topically to mice once daily for 14 days after wounding. To evaluate the effect of each extract, wound contraction, epithelization period, wound breaking strength, and hydroxyproline content were determined. The water extract of A. speciosa showed accelerated wound healing activity as evidenced by fast wound contraction (%; ), rapid epithelization period ( days; ), greater wound breaking strength ( g; ), and higher hydroxyproline content ( mg/g; ) of granulation tissue. The present report supports the traditional use of Argyreia speciosa leaves for wound healing and signify its relevant therapeutic potential.