Kinetics of Mushroom Tyrosinase and Melanogenesis Inhibition by N-Acetyl-pentapeptides

Table 1

N-Acetyl-pentapeptides inhibitory profile against diphenolase activity of mushroom tyrosinase.

N-Acetyl-pentapeptide	Peptide sequence	IC50 (mg/mL)
Ac-P1	Ac-RSRFK	0.75 ± 0.16
Ac-P2	Ac-KSRFR	0.78 ± 0.14
Ac-P3	Ac-KSSFR	0.81 ± 0.02
Ac-P4	Ac-RSRFS	0.29 ± 0.03*

Data are means ± SD of three replicates. Significantly different at *𝑃<0.05, compared to Ac-P1. Level as determined by one-way ANOVA followed by Duncan multiple range tests.