Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation

Table 1

Composition of immediate release core tablets of lercanidipine HCl.

Batch number	Ingredients (mg)									Total weight (mg)
	Drug	MCC	Lactose	PVP K30	SSG	Cross PVP	Ac-Di-Sol	Magnesium stearate	Talc
F 1	10.00	82.00	—	3.00	—	3.00	—	1.00	1.00	100
F 2	10.00	82.00	—	1.00	5.00	—	—	1.00	1.00	100
F 3	10.00	80.00	—	3.00	5.00	—	—	1.00	1.00	100
F 4	10.00	78.00	—	5.00	5.00	—	—	1.00	1.00	100
F 5	10.00	82.00	—	3.00	3.00	—	—	1.00	1.00	100
F 6	10.00	82.00	—	3.00	—	—	3.00	1.00	1.00	100
F 7	10.00	—	34.00	2.50	2.50	—	—	0.50	0.50	50
F 8	10.00	—	35.25	2.50	1.25	—	—	0.50	0.50	50
F 9	10.00	—	32.75	2.50	3.75	—	—	0.50	0.50	50
F 10	10.00	—	34.00	2.50	—	2.50	—	0.50	0.50	50
F 11	10.00	—	34.00	2.50	—	—	2.50	0.50	0.50	50