Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation

Table 4

Presentation of values and responses in central composite design.

Batch number	Factor 1; : PEO %	Factor 2; : coat weight (mg)	Response 1; Lag time (h)	Response 2; Release at 7 h (%)	Response 3; Release at 12 h (%)
FP 1	20.00	300.00	3	103.66	101.70
FP 2	20.00	400.00	3	99.69	98.87
FP 3	20.00	500.00	6	72.37	100.54
FP 4	30.00	300.00	3	78.86	99.96
FP 5	30.00	400.00	6	39.84	101.34
FP 6	30.00	500.00	7	2.07	105.86
FP 7	30.00	400.00	6	37.52	98.13
FP 8	30.00	400.00	6	39.28	100.15
FP 9	30.00	400.00	6	38.36	99.84
FP 10	30.00	400.00	6	40.25	100.06
FP 11	40.00	300.00	3	105.79	109.46
FP 12	40.00	400.00	7	19.70	84.61
FP 13	40.00	500.00	8	0.57	81.08