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The Scientific World Journal
Volume 2014, Article ID 424513, 12 pages
http://dx.doi.org/10.1155/2014/424513
Review Article

Solid Tumor-Targeting Theranostic Polymer Nanoparticle in Nuclear Medicinal Fields

1Biomedical Imaging Research Center (BIRC), University of Fukui, Fukui 910-1193, Japan
2Research and Education Program for Life Science, University of Fukui, Fukui 910-1193, Japan
3Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan

Received 27 June 2014; Revised 8 August 2014; Accepted 11 August 2014; Published 14 October 2014

Academic Editor: Masashi Ueda

Copyright © 2014 Akira Makino and Shunsaku Kimura. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polymer nanoparticles can be prepared by self-assembling of amphiphilic polymers, and various types of molecular assemblies have been reported. In particular, in medicinal fields, utilization of these polymer nanoparticles as carriers for drug delivery system (DDS) has been actively tried, and some nanoparticulate drugs are currently under preclinical evaluations. A radionuclide is an unstable nucleus and decays with emission of radioactive rays, which can be utilized as a tracer in the diagnostic imaging systems of PET and SPECT and also in therapeutic purposes. Since polymer nanoparticles can encapsulate most of diagnostic and therapeutic agents with a proper design of amphiphilic polymers, they should be effective DDS carriers of radionuclides in the nuclear medicinal field. Indeed, nanoparticles have been recently attracting much attention as common platform carriers for diagnostic and therapeutic drugs and contribute to the development of nanotheranostics. In this paper, recent developments of solid tumor-targeting polymer nanoparticles in nuclear medicinal fields are reviewed.