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The Scientific World Journal
Volume 2014, Article ID 429549, 7 pages
Review Article

Endovascular Intervention for Acute Ischemic Stroke in Light of Recent Trials

1Department of Surgery, University of Arizona, Tucson, AZ 85721, USA
2Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, PA 19107, USA
3Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA
4Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908, USA
5Department of Neurological Surgery, Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, 901 Walnut Street, 3rd Floor, Philadelphia, PA 19107, USA

Received 5 July 2014; Accepted 16 August 2014; Published 3 November 2014

Academic Editor: Stephen J. Monteith

Copyright © 2014 Kenan Alkhalili et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Three recently published trials, MR RESCUE, IMS III, and SYNTHESIS Expansion, evaluating the efficacy and safety of endovascular treatment of acute ischemic stroke have generated concerns about the future of endovascular approach. However, the tremendous evolution that imaging and endovascular treatment modalities have undergone over the past several years has raised doubts about the validity of these trials. In this paper, we review the role of endovascular treatment strategies in acute ischemic stroke and discuss the limitations and shortcomings that prevent generalization of the findings of recent trials. We also provide our experience in endovascular treatment of acute ischemic stroke.