Development and Optimization of Osmotically Controlled Asymmetric Membrane Capsules for Delivery of Solid Dispersion of Lycopene

Table 1

Experimental design for three factors and experimental values of responses.

Formulation; code	𝑋1; (ethyl cellulose); % w/v	𝑋2; (glycerol); % w/v	𝑋3; (NaCl); mg	𝑌1; (% cumulative drug Release)	𝑌2; (correlation coefficient)
F1	12.50	13.50	75.00	89.26	0.9923
F2	12.50	13.50	117.04	94.39	0.9825
F3	10.00	15.00	100.00	93.74	0.9245
F4	10.00	12.00	50.00	79.65	0.9820
F5	12.50	13.50	32.96	71.20	0.9714
F6	8.30	13.50	75.00	92.45	0.9526
F7	12.50	13.50	75.00	89.96	0.9918
F8	12.50	13.50	75.00	90.41	0.9921
F9	10.00	15.00	50.00	83.63	0.9245
F10	12.50	13.50	75.00	90.41	0.9951
F11	12.50	13.50	75.00	92.57	0.9829
F12	15.00	12.00	50.00	69.47	0.9975
F13	16.70	13.50	75.00	74.11	0.9986
F14	15.00	15.00	50.00	81.84	0.9842
F15	15.00	15.00	100.00	85.90	0.9198
F16	10.00	12.00	100.00	89.65	0.9185
F17	12.50	13.50	75.00	91.76	0.9914
F18	12.50	10.98	75.00	85.63	0.9994
F19	15.00	12.00	100.00	75.26	0.9982
F20	12.50	16.02	75.00	90.32	0.9725