Research Article

Synergistic Antitumor Effect of Doxorubicin and Tacrolimus (FK506) on Hepatocellular Carcinoma Cell Lines

Table 1

Doxorubicin and tacrolimus cotreatment induced a synergistic antiproliferative effect compared to treatment with drugs administered individually as demonstrated by median drug effect analysis calculating the combination index (CI) and the dose redaction index (DRI) with CalcuSyn software. “ ” is the linear correlation coefficient.

Cell lineTreatmentCI50 (±SD) (±SD)DRI (dox)DRI (tacr)

Huh7dox + tacr
HepG2dox + tacr