Tumor Necrosis Factor-α as a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis

Table 1

Characteristics of studies included in the meta-analysis of the diagnosis of neonatal sepsis using a TNF-𝛼 test.

Study	Study population	Patients (n)	Sepsis diagnosis	Cut-off (pg/mL)	Time	Country
Hotoura et al. 2012 [1]	Cases: newborns with suspected sepsis; Control: infection-free infants	82	Culture; clinical	30	LONS	Greece
Hotoura et al. 2012 [1]	Cases: newborns with suspected sepsis; Control: infection-free infants	82	Culture; clinical	15	LONS	Greece
Sherwin et al. 2008 [28]	Cases: NICU newborns with suspected sepsis; Control: neonates without sepsis	164	Culture; clinical	180	EONS	New Zealand
Sherwin et al. 2008 [28]	Cases: NICU newborns with suspected sepsis; Control: neonates without sepsis	164	Culture; clinical	70	LONS	New Zealand
Sherwin et al. 2008 [28]	Cases: NICU newborns with suspected sepsis; Control: neonates without sepsis	164	Culture; clinical	180	LONS	New Zealand
Kocabaş et al. 2007 [14]	Cases: neonates with a suspected clinical sepsis; Control: healthy neonates without infectious	55	Culture; clinical	7.5	LONS	Turkey
Fida et al. 2006 [18]	Cases: neonates with clinical or proven or possible infected sepsis; Control: disease without infection	28	Culture; clinical	29.86	EONS	Saudi Arabia
Park et al. 2004 [19]	Cases: newborns with suspected sepsis; Control: neonates without sepsis	77	Culture; clinical	41	EONS	Korea
Layseca-Espinosa et al. 2002 [20]	Cases: neonates with clinical or proven sepsis; Control: disease without infection	63	Culture; clinical	0.18	EONS	Spain
Martin et al. 2001 [21]	Cases: newborns with suspected sepsis; Control: neonates without sepsis	32	Culture; clinical	20	EONS	Sweden
Berner et al. 2000 [22]	Cases: newborns with suspected sepsis; Control: neonates without sepsis	31	Culture; clinical	48	EONS	Germany
Silveira and Procianoy 1999 [23]	Cases: newborn infants with clinical sepsis or probably infected with clinical sepsis; Control: neonates without sepsis	117	Culture; clinical	12	EONS	Brazil
Ng et al. 1997 [29]	Cases: VLBW infants with suspected clinical sepsis; Control: noninfected newborns	101	Culture; clinical	17	LONS	Hong Kong
Ng et al. 1997 [29]	Cases:VLBW infants with suspected clinical sepsis; Control: noninfected newborns	101	Culture; clinical	17	LONS	Hong Kong
Ng et al. 1997 [29]	Cases: VLBW infants with suspected clinical sepsis; Control: noninfected newborns	101	Culture; clinical	17	LONS	Hong Kong
Hotoura et al. 2011 [30]	Cases: full-term neonates; with suspected or documented infection; Control: infection-free infants	95	Culture; clinical	30	LONS	Greece
Hotoura et al. 2011 [30]	Cases: full-term neonates; with suspected or documented infection; Control: infection-free infants	95	Culture; clinical	15	LONS	Greece
Hallwirth et al. 2002 [24]	Cases: neonates with sepsis; Control: neonates without sepsis	25	Culture; clinical	20000	LONS	Austria
Procianoy and Silveira 2012 [25]	Cases: very low birth weight infants with clinical sepsis; Control: neonates without sepsis	84	Culture; clinical	30	EONS	Brazil
Shi et al. 1994 [26]	Cases: neonates with sepsis; Control: neonates without sepsis	67	Culture; clinical	267.2	EONS	CHINA
Ng et al. 2007 [27]	Cases: very low birth weight infants with suspected sepsis; Control: neonates without sepsis	155	Culture; clinical	0.6	EONS	Hong Kong
Ng et al. 2007 [27]	Cases: very low birth weight infants with suspected sepsis; Control: neonates without sepsis	155	Culture; clinical	0.6	EONS	Hong Kong
Hallwirth et al. 2002 [24]	Cases: neonates with sepsis; Control: neonates without sepsis	25	Culture; clinical	20000	EONS	Austria