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The Scientific World Journal
Volume 2014, Article ID 476912, 8 pages
Research Article

Observer Design for a Core Circadian Rhythm Network

School of Mathematics and Information Sciences, Henan University, Kaifeng 475004, China

Received 8 June 2014; Accepted 15 June 2014; Published 8 July 2014

Academic Editor: Guanghui Wen

Copyright © 2014 Yuhuan Zhang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The paper investigates the observer design for a core circadian rhythm network in Drosophila and Neurospora. Based on the constructed highly nonlinear differential equation model and the recently proposed graphical approach, we design a rather simple observer for the circadian rhythm oscillator, which can well track the state of the original system for various input signals. Numerical simulations show the effectiveness of the designed observer. Potential applications of the related investigations include the real-world control and experimental design of the related biological networks.