Manipulating Ratio Spectra for the Spectrophotometric Analysis of Diclofenac Sodium and Pantoprazole Sodium in Laboratory Mixtures and Tablet Formulation

Table 2

Accuracy and precision results of diclofenac and pantoprazole in bulk form using the proposed methods.

Amount added (µg/mL)	Intrabatch^a						Interbatch^b
	RPP		^1DD		MCR		RPP		^1DD		MCR
	Recovery (%)	% RSD	Recovery (%)	% RSD	Recovery (%)	% RSD	Recovery (%)	% RSD	Recovery (%)	% RSD	Recovery (%)	% RSD
Diclofenac
12.0	100.18	0.637	100.58	0.708	100.28	0.676	99.25	0.808	99.67	0.893	100.61	0.625
15.0	99.62	0.697	100.42	0.894	100.31	0.655	99.41	0.778	100.18	0.468	99.43	0.618
18.0	100.29	0.743	99.33	1.006	99.59	0.826	99.67	0.953	100.29	0.935	99.75	0.965
Pantoprazole
3.2	99.83	0.599	100.04	0.823	100.34	0.763	99.29	0.928	100.24	0.815	99.75	0.664
4.0	100.60	0.879	99.43	0.702	100.17	0.739	101.05	0.933	100.49	0.789	100.31	0.750
4.8	100.16	0.708	100.25	0.910	99.91	0.631	99.65	0.808	99.69	0.895	100.23	0.820

^aSamples analyzed in three replicates in the same day; ^bsamples analyzed in three replicates in three consecutive days; RPP: ratio spectra peak to peak measurement method; ¹DD: ratio derivative method; MCR: mean centering of ratio spectra method; % RSD: percent relative standard deviation.