Manipulating Ratio Spectra for the Spectrophotometric Analysis of Diclofenac Sodium and Pantoprazole Sodium in Laboratory Mixtures and Tablet Formulation

Table 3

Summary for the determination of diclofenac (DCL) and pantoprazole (PAN) in laboratory prepared mixtures by the proposed methods.

Concentration used (μg/mL)		% Recovery ± SD^a
		RPP		^1DD		MCR
DCL	PAN	DCL	PAN	DCL	PAN	DCL	PAN
8	8	99.63±0.61	100.36±0.44	99.86±0.87	100.24±0.67	100.42±0.47	99.95±0.80
8	10	100.42±0.74	100.55±0.87	99.55±0.58	101.02±0.77	100.43±0.55	100.55±0.58
8	16	99.78±0.96	100.19±0.86	99.94±0.79	100.39±0.63	100.02±0.74	100.71±0.89
10	8	100.63±0.73	99.48±0.56	100.58±0.74	100.30±0.62	99.77±0.67	99.72±0.94
10	10	100.72±0.89	99.92±0.61	100.12±0.71	100.41±0.83	100.19±0.62	99.90±0.68
10	16	99.42±0.76	100.49±0.62	100.07±0.98	99.83±0.58	99.98±0.76	99.77±0.95
16	8	99.90±0.69	99.76±0.95	100.77±0.97	99.63±0.76	99.84±0.50	99.64±0.62
16	10	100.32±0.57	100.46±0.88	99.90±0.68	99.86±0.84	99.66±0.61	100.48±0.59
Mean		100.04	100.09	100.10	100.15	100.10	100.21
Mean RSD (%)		0.617	0.758	0.744	0.723	0.793	0.714

aMean values of three replicates; RPP: ratio spectra peak to peak measurement method; ¹DD: ratio derivative method; MCR: mean centering of ratio spectra method; % RSD: relative standard deviation.