TY - JOUR A2 - Maček, P. A2 - Abdel-Rahman, S. Z. AU - Deng, Lihong AU - Lei, Jiandu AU - He, Jing AU - Liu, Jing AU - Wang, Luying AU - Zhang, Rui AU - Liu, Xinhua AU - Liu, Yun PY - 2014 DA - 2014/03/18 TI - Evaluation on Genotoxicity and Teratogenicity of Aqueous Extract from Cyclocarya paliurus Leaves SP - 498134 VL - 2014 AB - Tremendous attentions have been attracted to the foods labeled with natural, green, organic, and nuisanceless conception of healthy diet. Therefore, it is of great significance to establish relative defining guidance for safe assessment of botanicals. Cyclocarya paliurus (Batal.) Iljinsk (family Cyclocaryaceae), called sweet tea tree, is a well-known edible and medicinal plant, which has been widely used in China as drug formulation for the treatment of hypertension and diabetes. Despite its benefits, no reports have been described on the safe assessment of C. paliurus leaves aqueous extract. In this study, we have conducted the genotoxicity assay (including Ames test, bone marrow polychromatic erythrocyte micronucleus test, and sperm abnormality test in mice) and traditional teratogenicity assay in rats (maternal toxicity, embryo toxicity, and teratogenicity test) to assess the genetic and teratogenic safety of aqueous extracts from C. paliurus leaves. Results of each assay show that the highest dose of C. paliurus leaves aqueous extract is considered relatively nonmutagenic and nonteratogenic, revealing that C. paliurus leaves possess safety and quality as a functional additional ingredient in food. SN - 2356-6140 UR - https://doi.org/10.1155/2014/498134 DO - 10.1155/2014/498134 JF - The Scientific World Journal PB - Hindawi Publishing Corporation KW - ER -