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The Scientific World Journal
Volume 2014, Article ID 510627, 15 pages
Research Article

Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture

1The Engineering and Research Center of Southwest Bio-Pharmaceutical Resources, Ministry of Education, Guizhou University, Guiyang, Guizhou 550025, China
2Institute of Biology, Guizhou Academy of Sciences, Guiyang, Guizhou 550009, China
3Institute of Excellence in Fungal Research, School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
4Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11442, Saudi Arabia

Received 14 February 2014; Accepted 8 April 2014; Published 23 June 2014

Academic Editor: Rajesh Jeewon

Copyright © 2014 Chao Kang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • Zhuang-li Zheng, Xue-hong Qiu, and Ri-chou Han, “Identification of the genes involved in the fruiting body production and cordycepin formation of Cordyceps militaris fungus,” Mycobiology, vol. 43, no. 1, pp. 37–42, 2015. View at Publisher · View at Google Scholar
  • Joonyeob Lee, Taewoan Koo, Seokhwan Hwang, Kyungjin Cho, Seung Gu Shin, Hyokwan Bae, and Gyuseong Han, “Nutrient Recovery of Starch Processing Waste to Cordyceps militaris: Solid State Cultivation and Submerged Liquid Cultivation,” Applied Biochemistry and Biotechnology, vol. 180, no. 2, pp. 274–288, 2016. View at Publisher · View at Google Scholar
  • Ahmad Suparmin, Tatsuya Kato, Enoch Y. Park, and Nurmila Sari, “Improved cordycepin production in a liquid surface culture of Cordyceps militaris isolated from wild strain,” Biotechnology and Bioprocess Engineering, vol. 21, no. 5, pp. 595–600, 2016. View at Publisher · View at Google Scholar
  • Cai-Hong Dong, Kevin D. Hyde, Jing-Zu Sun, Xing-Zhong Liu, and Jian-Kui Liu, “Calcarisporium cordycipiticola sp. nov.,an important fungal pathogen of Cordyceps militaris,” Phytotaxa, vol. 268, no. 2, pp. 135–144, 2016. View at Publisher · View at Google Scholar
  • Wen, Long, Kang, Wang, and Zeng, “Effects of additives and bioreactors on cordycepin production from Cordyceps militaris in liquid static culture,” Mycosphere, vol. 8, no. 7, pp. 886–898, 2017. View at Publisher · View at Google Scholar
  • Wanwipa Vongsangnak, Nachon Raethong, Warasinee Mujchariyakul, Nam Ninh Nguyen, Hon Wai Leong, and Kobkul Laoteng, “Genome-scale metabolic network of Cordyceps militaris useful for comparative analysis of entomopathogenic fungi,” Gene, 2017. View at Publisher · View at Google Scholar
  • Liang-Tzung Lin, Ying-Jang Lai, She-Ching Wu, Wei-Hsuan Hsu, and Chen-Jei Tai, “Optimal conditions for cordycepin production in surface liquid-cultured Cordyceps militaris treated with porcine liver extracts for suppression of oral cancer,” Journal of Food and Drug Analysis, 2017. View at Publisher · View at Google Scholar
  • Jiafu Huang, Yixin Ou, Danfeng Zhang, Guoguang Zhang, and Yutian Pan, “Optimization of the culture condition of Bacillus mucilaginous using Agaricus bisporus industrial wastewater by Plackett–Burman combined with Box–Behnken response surface method,” AMB Express, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Yong Cao, Sanabil, Jingsheng Liu, Shuang Yang, Mingzhu Zheng, and Yanjiao Dong, “Optimization of liquid fermentation conditions for biotransformation zein by Cordyceps militaris 202 and characterization of physicochemical and functional properties of fermentative hydrolysates,” Brazilian Journal of Microbiology, vol. 49, no. 3, pp. 621–631, 2018. View at Publisher · View at Google Scholar
  • Kobkul Laoteng, Nachon Raethong, and Wanwipa Vongsangnak, “Uncovering global metabolic response to cordycepin production in Cordyceps militaris through transcriptome and genome-scale network-driven analysis,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  • Ji-Sun Shin, Soo-Hak Chung, Je-Young Lee, Kyung-Tae Lee, Woo-Seok Lee, and Jong-Lae Kim, “Immunostimulatory effects of cordycepin-enriched WIB-801CE from Cordyceps militaris in splenocytes and cyclophosphamide-induced immunosuppressed mice,” Phytotherapy Research, vol. 32, no. 1, pp. 132–139, 2018. View at Publisher · View at Google Scholar
  • Phongsakorn Kunhorm, Nipha Chaicharoenaudomrung, and Parinya Noisa, “Enrichment of cordycepin for cosmeceutical applications: culture systems and strategies,” Applied Microbiology and Biotechnology, 2019. View at Publisher · View at Google Scholar