Development and Optimization of Polymeric Self-Emulsifying Nanocapsules for Localized Drug Delivery: Design of Experiment Approach

Table 2

Combination levels of independent variables and the outcomes of response variables by Box-Behnken design.

Batch number	Independent factors			Actual value		Predicted value
	Capryol 90	HPMCAS-HF	Aerosil 200	Mean globule size (nm)	Encapsulation efficiency (%)	Mean globule size (nm)	Encapsulation efficiency (%)
P1				173.86	67.42	168.40	68.95
P2				194.84	96.18	189.01	94.68
P3				140.49	57.81	146.31	59.30
P4				172.06	59.15	177.51	57.61
P5				127.50	71.82	124.31	64.85
P6				180.02	67.05	177.20	63.11
P7				164.52	38.41	167.33	42.34
P8				163.07	61.16	166.25	68.12
P9				156.55	51.86	165.25	57.29
P10				164.35	39.90	161.70	45.36
P11				191.87	65.44	194.51	59.97
P12				173.07	30.61	164.43	25.18
P13				173.07	71.01	176.31	71.31
P14				180.91	70.79	176.31	71.31
P15				169.87	69.76	176.31	71.31
P16				184.81	75.05	176.31	71.31
P17				172.92	69.96	176.31	71.31

Standard deviation of the observed responses was within ±5% ().