Development and Optimization of Polymeric Self-Emulsifying Nanocapsules for Localized Drug Delivery: Design of Experiment Approach

Table 3

Regression analysis for mean globule size and encapsulation efficiency.

Response	Model	Std. dev.	^2	Adjusted ^2	Remarks
Mean globule size (nm)	Linear	12.79	0.532	0.424	Suggested
	Second order	10.93	0.737	0.579	—
	Quadratic	8.31	0.893	0.756	Suggested
	Cube	6.26	0.965	0.862	Aliased
Encapsulation efficiency (%)	Linear	13.60	0.389	0.248	—
	Second order	13.77	0.518	0.229	—
	Quadratic	6.26	0.930	0.840	Suggested
	Cube	2.15	0.995	0.981	Aliased